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Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation

A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-

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Approximately 70 percent of GPX3 is secreted by the basolateral membrane of renal proximal convoluted tubule (PCT) cells and into plasma through the basilar artery (Zhao et al., 2019